1. Understand the Pharmacological Profiles of Remimazolam and Propofol o Compare the pharmacokinetics, metabolism, and elimination pathways of remimazolam and propofol. o Discuss the implications of context-sensitive half-time (CSHT) and effect-site concentration in clinical practice. 2. Analyze the Design and Methodology of a Non-Inferiority Trial o Review the structure of a multicenter, randomized controlled trial (RCT) including inclusion/exclusion criteria, sample size calculation, and blinding. o Understand the rationale and statistical considerations behind non-inferiority trials. 3. Evaluate Depth of Anaesthesia Monitoring Techniques o Compare Narcotrend and BIS monitors in terms of reliability and clinical application. o Discuss how depth of anaesthesia monitoring influences intraoperative decision-making and patient safety. 4. Interpret Primary and Secondary Outcomes o Assess anaesthetic efficacy based on Narcotrend Index values. o Examine secondary outcomes including post-induction hypotension, time to extubation, and recovery parameters. 5. Critically Appraise the Study’s Findings and Clinical Relevance o Discuss whether remimazolam is a viable alternative to propofol in ASA III–IV patients. o Explore the implications of reduced hypotension with remimazolam and its potential impact on practice. 6. Reflect on Practical Applications and Future Research o Identify scenarios where remimazolam may be preferred over propofol. o Propose areas for further investigation, such as its use in high-risk populations or specific surgical settings. 7. Promote Evidence-Based Decision-Making in Anaesthesia o Encourage critical thinking around drug selection, monitoring strategies, and perioperative planning. o Foster discussion on integrating new evidence into clinical protocols and guidelines.