MANAGING AND MONITORING FOR AMPHOTERIN B THERAPY Should always be used for induction when available. Alternative flucytosine 100mg/kg per day divided into four doses per day. Prehydrate with 1 L of normal saline with 20 mmol of KCl over 2-4 hours before each controlled infusion of Ampho B. Darrows or Ringer’s solutions can also be used  Causes hypokalemia thus UECS should be done on alternate days. If K < 3.3 mmol/L, administer 1 L of normal saline with KCl 40 mmol in normal saline or 1-2 tablets of 8mEq KCl every 8 hours. Add magnesium. Monitor potassium daily  If creatinine level increases > 2-fold from baseline, omit dose of Ampho B, increase hydration to 1 L every 8 hours. If there’s improvement, re-start Ampho B at 0.7 mg/kg/day on alternate days. If no improvement, discontinue Ampho B, give fluconazole 1,600 mg/day to complete induction. Monitor creatinine daily  Other effects of amphoB: Anemia Allergic reactions that could present as fever Hypotension