Starting on:
May 21, 2025
Ending on:
May 21, 2025
Moderator(s):
Venue:
KUTRRH
Max Credits:
3 Points
Provider:
Kenyatta University Teaching and Referral Hospital
Claim Points
May 21, 2025
Ending on:
May 21, 2025
Moderator(s):
KUTRRH
Max Credits:
3 Points
Provider:
Kenyatta University Teaching and Referral Hospital
Claim Points
Rhabdomyosarcoma
Starting on:
May 21, 2025
May 21, 2025
Ending on:
May 21, 2025
May 21, 2025
Venue:
KUTRRH
KUTRRH
Description
Introduction Rhabdomyosarcoma is a highly aggressive/ malignant form of soft tissue sarcoma that develops from unsegmented, undifferentiated mesoderm or myotome-derived skeletal muscle. Cells of the tumor are identified as rhabdomyoblasts. RMS can arise almost anywhere in the body, is locally invasive, and rapidly disseminates early in its course.
Objectives
Causes/ Risk Factors
Cause of RMS is unknown;
Environmental exposures -paternal cigarette use, prenatal x-ray exposure, and maternal recreational drug use.
Disorders in development, including central nervous system, genitourinary, gastrointestinal, and cardiovascular anomalies
With congenital disorders - congenital pulmonary cysts. Gorlin basal cell nevus syndrome, neurofibromatosis, Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome, and Costello syndrome.
Mutations-Alveolar RMS associated two translocations,t(2;13) (p35; q14),present in about 60% of children with alveolar RMS. The less common translocation, t(1;13)(p36;q14). Embryonal RMS characterized by loss of heterozygosity at 11p15.5,n-myc amplification,p53 mutation also seen.
Presenters
-
Dr.
Everlyne Maingi
Dr.